GWAS

GWAS in epilepsy are appearing more regularly. The data from such GWAS are considerable, and we will see how best we can present the massive amount of information that derives from a GWAS.

For the moment, we are providing links to the abstracts:

Kasperaviciute et al, Brain 2010

Guo et al, Hum Mol Genet 2012

EPICURE & EMINET consortia, Hum Mol Genet 2012

Heinzen et al, Am J Hum Genet 2012

Speed et al, Hum Mol Genet 2014.

The ILAE Consortium on Complex Epilepsies, Lancet Neurology 2014.  Meta-data from this publication on genetic determinants of common epilepsiescan be downloaded here from epiGAD.

The ILAE Consortium on Complex Epilepsies, Neurology 2018. Data from this publication on phenytoin-induced maculopapular exanthema can be downloaded here from epiGAD.

The ILAE Consortium on Complex Epilepsies, Nature Communications 2018. Data from this publication on 16 loci in common epilepsies can be downloaded here from epiGAD

ILAE Consortium on Complex Epilepsies. Genome-wide meta-analysis of over 29,000 people with epilepsy reveals 26 loci and subtype-specific genetic architecture. Summary statistics (1.8GB zipfile) here