This page contains 10 summary statistics files (3 METAL files and 7 BOLT-LMM files) to accompany the epilepsy GWAS paper by the International League Against Epilepsy Consortium on Complex Epilepsies, published in Nature Communications.

METAL files (trans-ethnic meta-analyses of 3 broad epilepsy phenotypes) with the following columns:
- CHR - chromosome
- BP - physical (base pair) position
- MarkerName - rs number
- Allele1 - the first allele for this marker in the first file where it occurs; used as the effect allele
- Allele2 - the second allele for this marker in the first file where it occurs; used as the non-effect allele
- Freq1 - frequency of the first allele
- FreqSE - standard error of the frequency of the first allele
- Weight - the sum of the individual study weights for this marker. Individual study weights are calculated with the formula: 4 / (1/[# of cases] + 1/[# of controls])
- Z-score - the combined z-statistic for this marker
- P-value - meta-analysis p-value
- Direction - summary of effect direction for each study (see below), with one '+' or '-' per study
- HetISq - I^2 statistic which measures heterogeneity on scale of 0-100%
- HetChiSq - chi-squared statistic in simple test of heterogeneity
- df - degrees of freedom for heterogeneity statistic
- HetPVal - P-value for heterogeneity statistic

BOLT-LMM files (Caucasian-only analyses of 7 epilepsy subphenotypes) with the following columns:
- SNP - rs number
- CHR - chromosome
- BP - physical (base pair) position
- GENPOS - genetic position either from bim file or interpolated from genetic map
- ALLELE1 - first allele in bim file (usually the minor allele), used as the effect allele
- ALLELE0 - second allele in bim file, used as the non-effect (reference) allele
- A1FREQ - frequency of first allele
- F_MISS - fraction of individuals with missing genotype at this SNP
- BETA - effect size from BOLT-LMM approximation to infinitesimal mixed model
- SE - standard error of effect size
- P_BOLT_LMM_INF - infinitesimal mixed model association test p-value


all_epilepsy_METAL.gz
CAE_BOLT-LMM_final.gz
focal_epilepsy_METAL.gz
focal_HS_BOLT-LMM_final.gz
focal_lesion_negative_BOLT-LMM_final.gz
focal_other_lesion_BOLT-LMM_final.gz
generalised_epilepsy_METAL.gz
GTCS_BOLT-LMM_final.gz
JAE_BOLT-LMM_final.gz
JME_BOLT-LMM_final.gz
README.txt