This page contains 10 summary statistics files (3 METAL files and 7 BOLT-LMM files) to accompany the epilepsy GWAS paper by the International League Against Epilepsy Consortium on Complex Epilepsies, published in Nature Communications.

**METAL files (trans-ethnic meta-analyses of 3 broad epilepsy phenotypes) with the following columns: **

- CHR - chromosome

- BP - physical (base pair) position

- MarkerName - rs number

- Allele1 - the first allele for this marker in the first file where it occurs; used as the effect allele

- Allele2 - the second allele for this marker in the first file where it occurs; used as the non-effect allele

- Freq1 - frequency of the first allele

- FreqSE - standard error of the frequency of the first allele

- Weight - the sum of the individual study weights for this marker. Individual study weights are calculated with the formula: 4 / (1/[# of cases] + 1/[# of controls])

- Z-score - the combined z-statistic for this marker

- P-value - meta-analysis p-value

- Direction - summary of effect direction for each study (see below), with one '+' or '-' per study

- HetISq - I^2 statistic which measures heterogeneity on scale of 0-100%

- HetChiSq - chi-squared statistic in simple test of heterogeneity

- df - degrees of freedom for heterogeneity statistic

- HetPVal - P-value for heterogeneity statistic

**BOLT-LMM files (Caucasian-only analyses of 7 epilepsy subphenotypes) with the following columns:
**

- SNP - rs number

- CHR - chromosome

- BP - physical (base pair) position

- GENPOS - genetic position either from bim file or interpolated from genetic map

- ALLELE1 - first allele in bim file (usually the minor allele), used as the effect allele

- ALLELE0 - second allele in bim file, used as the non-effect (reference) allele

- A1FREQ - frequency of first allele

- F_MISS - fraction of individuals with missing genotype at this SNP

- BETA - effect size from BOLT-LMM approximation to infinitesimal mixed model

- SE - standard error of effect size

- P_BOLT_LMM_INF - infinitesimal mixed model association test p-value

all_epilepsy_METAL.gz

CAE_BOLT-LMM_final.gz

focal_epilepsy_METAL.gz

focal_HS_BOLT-LMM_final.gz

focal_lesion_negative_BOLT-LMM_final.gz

focal_other_lesion_BOLT-LMM_final.gz

generalised_epilepsy_METAL.gz

GTCS_BOLT-LMM_final.gz

JAE_BOLT-LMM_final.gz

JME_BOLT-LMM_final.gz

README.txt