This page contains 10 summary statistics files (3 METAL files and 7 BOLT-LMM files) to accompany the epilepsy GWAS paper by the International League Against Epilepsy Consortium on Complex Epilepsies, published in Nature Communications.

METAL files (trans-ethnic meta-analyses of 3 broad epilepsy phenotypes) with the following columns:

- CHR			- chromosome
- BP			- physical (base pair) position
- MarkerName    - rs number
- Allele1  		- the first allele for this marker in the first file where it occurs; used as the effect allele
- Allele2	 	- the second allele for this marker in the first file where it occurs; used as the non-effect allele
- Freq1 		- frequency of the first allele
- FreqSE		- standard error of the frequency of the first allele
- Weight    	- the sum of the individual study weights for this marker. Individual study weights are calculated with the formula: 4 / (1/[# of cases] + 1/[# of controls])
- Z-score   	- the combined z-statistic for this marker
- P-value   	- meta-analysis p-value
- Direction 	- summary of effect direction for each study (see below), with one '+' or '-' per study
- HetISq    	- I^2 statistic which measures heterogeneity on scale of 0-100%
- HetChiSq  	- chi-squared statistic in simple test of heterogeneity
- df        	- degrees of freedom for heterogeneity statistic
- HetPVal   	- P-value for heterogeneity statistic



BOLT-LMM files (Caucasian-only analyses of 7 epilepsy subphenotypes) with the following columns:

- SNP 			- rs number
- CHR 			- chromosome
- BP			- physical (base pair) position
- GENPOS 		- genetic position either from bim file or interpolated from genetic map
- ALLELE1		- first allele in bim file (usually the minor allele), used as the effect allele
- ALLELE0 		- second allele in bim file, used as the non-effect (reference) allele
- A1FREQ 		- frequency of first allele
- F_MISS 		- fraction of individuals with missing genotype at this SNP
- BETA 			- effect size from BOLT-LMM approximation to infinitesimal mixed model
- SE 			- standard error of effect size
- P_BOLT_LMM_INF - infinitesimal mixed model association test p-value